The humor in "Boys Club" is often rooted in the characters’ everyday experiences, absurdity, and surreal scenarios. The comic's art style is colorful and whimsical, which complements the light-hearted and often bizarre nature of the stories.

Pepe the Frog, one of the characters from "Boys Club," gained widespread recognition outside the comic. Originally, Pepe became popular on internet forums like 4chan and later became a versatile meme. Unfortunately, the character was appropriated by various groups for different, sometimes controversial, purposes. This led to Matt Furie’s efforts to reclaim and rehabilitate Pepe’s image, including legal actions and a campaign to restore Pepe’s original, positive connotations.